World War D
The Case against prohibitionism,
roadmap to controlled re-legalization

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Prohibitionism and the War on Drugs

Prohibitionism, a 19th century totalitarian ideology • Settlement patterns and prohibitionism • The temperance movement • The psychoactive landscape at the dawn of prohibition
Moral panics and the build-up to the Harrison Tax Act of 1914 • The noble experiment • Moral panic revisited: Harry Anslinger and the 1937 Marihuana Tax Bill • Narcotics and the mob • Early dissenters
Nixon era • Build-up to the 1980s cocaine craze • Klaus Barbie and the Bolivian cocaine coup • Reagan era • The age of stupid • The Iran-Contras crack cocaine connection • The rise and fall of the Medellín Cartel • The aftermath: more of the same • The never-ending saga • The Mexican decades
Prohibition in a market economy • Modus operandi of the illegal drug trade • Current trends in the illegal psychoactive marketplace
legal and illegal drug-related casualties in the US, EU, and throughout the world • Societal cost of drug use • Taxpayers cost of the War on Drugs in the US • Health costs of the War on Drugs • Human cost of the War on Drugs in the US • Conclusion to Section 1

Major legal and illegal psychoactive substances, their actions and benefits, and their harm-causing

Homeostasis, a key adaptive process • Cells for starters • Brain 1.01 • Neurotransmission • Neuroplasticity • Neurotransmission and psychoactive substances • Major neurotransmitters • The endocannabinoid system • The pleasure/reward pathway in the brain • The brain reward pathway and the pursuit of happiness • The addiction puzzle • Vulnerability and resistance to abuse and addiction • Hallucinogens and other types of mind alteration • The mind alteration drive
Modes of administration – evolutionary adaptive gaps • Psychoactive substances and the growing brain • Patterns of use – Drug careers – Use, abuse and addiction • The issue of initiation • Subcultures appropriation of Psychoactives – Global youth culture
Moonshining from outer space to the “Wine Pool and Meat Forest”: A brief history of booze • Alcohol in Indo-European cultures and Western civilization • Pharmacokinetics of alcohol • Metabolic elimination of alcohol in the liver • Effects of alcohol on the body • Alcohol and the brain • Alcohol use patterns • The socio-economic cost of alcohol
The addictive power of Tobacco • Medical uses and health benefits of tobacco
Main classes of prescription psychoactive drugs • The patent engine • Cosmetic psychopharmacology – the “worried well” and the medicalization of normalcy • Prescription psychoactive drug abuse, a 21st century epidemic • Addiction by prescription – Big Pharma and greed addiction • Conclusion
Cannabis and Cannabinoids • Opiates • Cocaine • Amphetamines and ATS stimulants • Ecstasy – Designers drugs/party drugs • Hallucinogens • LSD • Other hallucinogens – psilocybin/magic mushroom, mescaline/peyote • Multi-substance use • Conclusion to section 2

Beyond the War on Drugs

Indulgence and hypocrisy at the top • US • Latin America • EU • India • The International Community: UN, WHO, UNESCO, etc.
The flawed prohibitionist model • Prohibitionism and moral relativism: Faulty premises and false assumptions of prohibitionism • Prohibition is not practically and efficiently enforceable • The resilience of the prohibitionist model • Prohibitionism and ulterior motives
What is harm reduction? • The cost issue • Excise tax • Lessons learned from other harms • Harms related to illegal drug use • Harms related to the use of psychoactive substances • Harms caused by drug prohibition • The cost of madness
The limits of decriminalization • Selective legalization • The case for legalization • Limits of the pure free market approach • Global legalization of production, consumption and trade • Controlled re-legalization is the only realistic option for emerging countries • Expected US opposition to controlled re-legalization and why it may not matter • Winners and losers of re-legalization • Legalization and the UN • The danger of a free-for-all approach and the urgency of coordination
Re-legalize • Tax • Control • Regulatory options • Regulatory issues: • Regulating production and wholesale trade • Educate and prevent • Treat • The issue of under-age substance use and abuse • Harm reduction to be expected from controlled re-legalization • Harm augmentation that can be expected from re-legalization

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